Circuits implicated in anxiety-related behaviour in rodents

The sagittal view of a rodent brain shown on the slide highlights some circuits that have been linked to anxiety-like behaviours.² Many brain areas regulate emotion – including the amygdala, medial prefrontal cortex, the hippocampus, and the bed nucleus of the stria terminalis – these areas are interconnected forming complex neural circuits that mediate anxiety.¹

References:

1. Zhao H, Zhou M, Liu Y, et al. Recent advances in anxiety disorders: focus on animal models and pathological mechanisms. Animal Model Exp Med 2023; 6 (6): 559–572.
2. Calhoon GG, Tye KM. Resolving the neural circuits of anxiety. Nat Neurosci 2015; 18 (10): 1394–1404.