Large-scale multi-ancestry GWAS of anxiety disorders

This genome-wide analysis combined data from six cohorts of people from different ancestry, giving new insights into the genetics of anxiety disorders.¹ Among the strongest signals was that for the locus DRD2, which encodes the dopamine D2 receptor.¹ Dopamine function is known to be linked to psychiatric disorders, and this analysis suggests the importance of cerebellar dopamine signalling in anxiety disorders.¹

Reference:

1. Friligkou E, Løkhammer S, Cabrera-Mendoza B, et al. Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study. Nat Genet 2024; 56 (10): 2036–2045.