Although such studies have been enlightening, there are challenges to studying the ‘high-risk’ children of people with bipolar disorder.2 There is a high degree of phenotypic and aetiologic heterogeneity amongst these children, and many of the early symptoms investigated are non-specific.2
References:
1. Faedda GL, Baldessarini RJ, Marangoni C, et al. An International Society of Bipolar Disorders task force report: precursors and prodromes of bipolar disorder. Bipolar Disord 2019; 21 (8): 720–740.
2. Duffy A, Vandeleur C, Heffer N, Preisig M. The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations. Int J Bipolar Disord 2017; 5 (1): 37.