Long-term treatment of bipolar disorder with antidepressants is not recommended, due to a risk of manic/hypomanic switching.1
References:
1. Yatham LN, Kennedy SH, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord 2018; 20 (2): 97–170.
2. Yatham LN, Arumugham SS, Kesavan M, et al; BEAM-BD Trial Group. Duration of adjunctive antidepressant maintenance in bipolar I depression. N Engl J Med 2023; 389 (5): 430–440.