The genome-wide association study (GWAS) outlined on the slide validated some previous GWAS data,2 and went further adding more potential genomic loci of interest.1 A previous GWAS had used data from 20,352 people with BD and 31,358 controls, and identified 30 loci associated with BD, including genes encoding ion channels, neurotransmitter receptors, and synaptic components.2 The GWAS results outlined on the slide identified several gene loci already implicated in bipolar disorder or other psychiatric disorders, including gene targets of antipsychotics, calcium channel blockers, antiepileptics, and anesthetics.1
References:
1. Mullins N, Forstner AJ, O’Connell KS, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet 2021; 53 (6): 817–829.
2. Stahl EA, Breen G, Forstner AJ, et al.; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet 2019; 51 (5): 793–803.