Epileptogenesis – how does enduring susceptibility to seizures occur?

Many neurophysiological changes occur within the brain during seizures, a range of interacting changes including some that compensate for others, which together drive epilepsy pathology.¹ The wideness of the range of known epileptogenic mechanisms suggests a complex web of interacting pathology that drives the development of epilepsy.¹

References:

1.Devinsky O, Vezzani A, O’Brien TJ, et al. Epilepsy. Nat Rev Dis Primers 2018; 4 (3): 18024.

2.Engel J Jr. Epileptogenesis, traumatic brain injury, and biomarkers. Neurobiol Dis 2019; 123: 3–7.

3.González MI, Brooks-Kayal A. Altered GABA(A) receptor expression during epileptogenesis. Neurosci Lett 2011; 497 (3): 218–222.