The presence of psychiatric and physical comorbidities adversely affects health outcomes and general functioning, and increases treatment costs and healthcare resource utilization in people with MDD.2,4 MDD comorbid with another medical disorder is also strongly associated with a reduction in the ability to work full-time, and with an increase in disability.4
References:
1.Steffen A, Nübel J, Jacobi F, et al. Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data. BMC Psychiatry 2020; 20: 142.
2.Berk M, Köhler-Forsberg O, Turner M, et al. Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management. World Psychiatry 2023; 22: 366–387.
3.Hirschfeld RA. The comorbidity of major depression and anxiety disorders: Recognition and management in primary care. Prim Care Companion J Clin Psychiatry 2001; 3 (6): 244–254.
4.Baune BT, Adrian I, Jacobi F. Medical disorders affect health outcome and general functioning depending on comorbid major depression in the general population. J Psychosom Res 2007; 62 (2): 109–118.
