Patients frequently discontinue treatment due to side effects

Adverse events of antidepressant therapy can be a significant factor in the decision to discontinue antidepressant treatment, as outlined on the slide.^1-3

References:
1.Kelly K, Posternak M, Alpert JE. Toward achieving optimal response: understanding and managing antidepressant side effects. Dialogues Clin Neurosci 2008; 10 (4): 409–418.

2.Bet PM, Hugtenburg JG, Penninx BWJH, Hoogendijk WJG. Side effects of antidepressants during long-term use in a naturalistic setting. Eur Neuropsychopharmacol 2013; 23 (11): 1443–1451.

3.Hu XH, Bull SA, Hunkeler EM, et al. Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate. J Clin Psychiatry 2004; 65 (7): 959–965.