Migraine with aura, and migraine without aura

There are important differences between migraine with aura and without aura, as outlined on the slide. However – perhaps because of the lack of clinical studies stratified based on the presence of aura symptoms – it is not clear whether migraine with aura and without aura ought to be treated differently.^{[Hansen & Charles, 2019]} More research is needed, specifically studies with clear distinctions between people with and without aura, to understand how the presence of aura symptoms should influence treatment options.^{[Hansen & Charles, 2019]}

Reference:
Hansen JM, Charles A. Differences in treatment response between migraine with aura and migraine without aura: lessons from clinical practice and RCTs. J Headache Pain 2019; 20 (1): 96.

Other references used on slide:
Gervil M, Ulrich V, Kyvik KO, et al. Migraine without aura: a population-based twin study. Ann Neurol 1999; 46 (4): 606–611.

Hauge AW, Hougaard A, Olesen J. On the methodology of drug trials in migraine with aura. Cephalalgia 2010; 30 (9): 1041–1048.

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3^rd edition. Cephalalgia 2018; 38 (1): 1–211.

Shankar Kikkeri N, Nagalli S. Migraine with Aura. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2020. Available at: https://www.ncbi.nlm.nih.gov/books/NBK554611/. Accessed January 2020.

Ulrich V, Gervil M, Kyvik KO, et al. Evidence of a genetic factor in migraine with aura: a population-based Danish twin study. Ann Neurol 1999; 45 (2): 242–246.