Migraine epidemiology

Migraine is a burdensome condition.^{[GBD, 2017; Steiner et al., 2018; Buse et al., 2020]} The Migraine in America Symptoms and Treatment (MAST) study was an internet-based survey that questioned people with migraine about their headaches.^{[Buse et al., 2020]} The results showed that migraine was associated with high levels of disability and comorbidity.^{[Buse et al., 2020]} People with migraine were significantly more likely to report:^{[Buse et al., 2020]}

• insomnia (odds ratio [OR]: 3.79, 95% confidence interval [CI]: 3.6, 4.0)
• anxiety (OR: 3.18, 95% CI: 3.0, 3.3)
• gastric ulcers or gastrointestinal bleeding (OR: 3.11, 95% CI: 2.8, 3.5)
• angina (OR: 2.64, 95% CI: 2.4, 3.0)
• epilepsy (OR: 2.33, 95% CI: 2.0, 2.8).

References:
Buse DC, Reed ML, Fanning KM, et al. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the Migraine in America Symptoms and Treatment (MAST) study. J Headache Pain 2020; 21 (1): 23.

GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392 (10159): 1789–1858.

Steiner TJ, Stovner LJ, Vos T, et al. Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain 2018; 19 (1): 17.

Other reference used on slide:
Gasparini CF, Sutherland HG, Griffiths LR. Studies on the pathophysiology and genetic basis of migraine. Curr Genomics 2013; 14 (5): 300–315.