Over the last century, there has been much progress in understanding the pathology underlying migraine.[Tfelt-Hansen & Koehler, 2011] Key scientific and clinical milestones are detailed on the slide, including some of the key events in the development of migraine therapies that target CGRP.[Tfelt-Hansen & Koehler, 2011; Edvinsson et al., 2018]

References:
Edvinsson L, Haanes KA, Warfvinge K, Krause DN. CGRP as the target of new migraine therapies – successful translation from bench to clinic. Nat Rev Neurol 2018; 14 (6): 338–350.

Tfelt-Hansen PC, Koehler PJ. One hundred years of migraine research: major clinical and scientific observations from 1910 to 2010. Headache 2011; 51 (5): 752–778.