Cortical spreading depression

The seminal publication of Aristides Leão in 1944 reported the experimental ability to temporarily suppress electrical activity in an area of the brain (specifically, a rabbit brain), and this suppression then slowly spread into neighbouring areas.^{[Leão, 1944]} This spreading could be blocked by physical incision in the cortex.^{[Leão, 1944; McComas & Upton, 2015]} Later experiments explored the phenomenon more thoroughly, linking this CSD with vascular changes, and showing that CSD could occur in more superficial layers of the cortex.^{[McComas & Upton, 2015]}

References:
Leão AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 1944; 7 (6): 359–390.

McComas AJ, Upton ARM. Cortical spreading depression in migraine – time to reconsider? Arq Neuropsiquiatr 2015; 73 (8): 714–721.

Other reference used on slide:
Charles A, Brennan K. Cortical spreading depression – new insights and persistent questions. Cephalalgia 2009; 29 (10): 1115–1124.