One of the first therapies for migraine – an ergot alkaloid – works by vasoconstriction; this led to attempts to unravel the pathology of migraine by focussing on the vasculature.[Mason & Russo, 2018; Charles & Brennan, 2010] However, although vascular changes do occur during a migraine, it is not yet clear to what extent these changes cause, or are a result of, the migraine pathology and the resulting pain.[Mason & Russo, 2018]
References:
Charles A, Brennan KC. The neurobiology of migraine. Handb Clin Neurol 2010; 97: 99–108.
Other reference used on slide:
Olesen J, Friberg L, Olsen TS, et al. Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 1990; 28 (6): 791–798.