Inflammation and the role of the immune system

Migraine has not classically been considered an inflammatory condition, perhaps because, other than pain, migraine is not obviously associated with signs of inflammation (redness, heat, and swelling).^{[Waeber & Moskowitz, 2005]} A question that immediately arises, then, is how to define neurogenic inflammation. Neurogenic inflammation is usually considered a phenomenon of vasodilation and of increased vascular permeability, caused by the interaction of neuropeptide mediators and proinflammatory chemicals.^{[Malhotra, 2016]} Examples of neuropeptides that can promote neuroinflammation are CGRP, and substance P.^{[Malhotra, 2016]}

References:
Malhotra R. Understanding migraine: potential role of neurogenic inflammation. Ann Indian Acad Neurol 2016; 19 (2): 175–182.

Waeber C, Moskowitz MA. Migraine as an inflammatory disorder. Neurology 2005; 64 (10 Suppl. 2): S9–S15.

Other references used on slide:
Charles A, Brennan KC. The neurobiology of migraine. Handb Clin Neurol 2010; 97: 99–108.

Edvinsson L, Haanes KA, Warfvinge K. Does inflammation have a role in migraine? Nat Rev Neurol 2019; 15 (8): 483–490.

Vanmolkot KRJ, Kors EE, Turk U, et al. Two de novo mutations in the Na, K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine. Eur J Hum Genet 2006; 14 (5): 555–560.