Migraine pathogenesis and the role of CGRP – trigeminal nucleus caudalis

Neurons of the trigeminal ganglion (TG) project to the trigeminal nucleus caudalis (TNC) of the brainstem.^{[Iyengar et al., 2019]} With connections to the meninges, the trigeminovascular system, more broadly, is thought to mediate nociception in the dura mater of the meninges.^{[Iyengar et al., 2019]}

Reference:
Iyengar S, Johnson KW, Ossipov MH, Aurora SK. CGRP and the trigeminal system in migraine. Headache 2019; 59 (5): 659–681.

Other references used on slide:
Jansen-Olesen I, Baun M, Amrutkar DV, et al. PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor. Neuropeptides 2014; 48 (2): 53–64.

Russo AF. Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol 2015; 55: 533–552.

Schytz HW, Birk S, Wienecke T, et al. PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 2009; 132 (Pt 1): 16–25.