Historical context for migraine treatment

There have been many historical approaches to treating headaches,^{[Koehler & Boes, 2010; Pearce, 1986]} but modern approaches centre around the use of analgesics, NSAIDs, and more targeted therapies, such as triptans and CGRP related agents.^{[Martelletti & Giamberardino, 2019]} Although these approaches are efficacious in many patients, there remains an unmet need for well-tolerated therapies that can be easily handled and administered by patients.^{[Martelletti & Giamberardino, 2019]}

References:
Koehler PJ, Boes CJ. A history of non-drug treatment in headache, particularly migraine. Brain 2010; 133 (Pt 8): 2489–2500.

Martelletti P, Giamberardino MA. Advances in orally administered pharmacotherapy for the treatment of migraine. Expert Opin Pharmacother 2019; 20 (2): 209–218.

Pearce JM. Historical aspects of migraine. J Neurol Neurosurg Psychiatry 1986; 49 (10): 1097–1103.

Other references used on slide:
Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the American Headache Society evidence assessment of migraine pharmacotherapies. Headache 2015; 55 (1): 3–20.

Silberstein SD. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000; 55 (6): 754–762.

Worthington I, Pringsheim T, Gawel MJ, et al. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci 2013; 40 (5 Suppl 3): S1–S80.