Bradykinesia refers to a slowness of movement.1 Patients with PD often report feeling clumsy or slow, and this may be misinterpreted by family members as a ‘normal’ part of ageing.6 Bradykinesia can manifest in different ways, but it always appears at some point during PD and inevitably worsens as the disease progresses.5,6

Patients with bradykinesia are often limited in their ability to perform repetitive movements, such as tapping their foot on the floor, or opening and closing the hand.5 They typically struggle to maintain both speed and range of motion (‘amplitude’).5 Symptoms tend to be asymmetrical, affecting one side more than the other, so when walking patients with bradykinesia may display reduced arm swing on the more affected side.5,6 Initiation of movement can also be difficult (e.g., when starting to walk),5 and sometimes patients pause mid-movement, causing them to appear frozen.6

Earlier and more subtle signs of bradykinesia may include reductions in spontaneous movement, such as facial expressions (‘hypomimia’), as well as less non-verbal communication through gesticulation.6 The voice may become increasingly soft (‘hypophonia’), and handwriting smaller and more laboured (‘micrographia’).5,7

References:
1.Jankovic J. Pathophysiology and assessment of parkinsonian symptoms and signs. In: Pahwa R, Lyons KE, Koller WC (eds). Handbook of Parkinson’s Disease, 3rd edition. Boca Raton: CRC Press, 2003.

2.Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015; 30 (12): 1591–1601.

3.Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet 2021; 397 (10291): 2284–2303.

4.Ellis T, Cavanaugh JT, Earhart GM, et al. Which measures of physical function and motor impairment best predict quality of life in Parkinson’s disease? Parkinsonism Relat Disord 2011; 17 (9): 693–697.

5.Massano J, Bhatia KP. Clinical approach to Parkinson’s disease: features, diagnosis, and principles of management. Cold Spring Harb Perspect Med 2012; 2 (6): a008870.

6.Williams DR, Litvan I. Parkinsonian syndromes. Continuum (Minneap Minn) 2013; 19 (5): 1189–1212.

7.Wagle Shukla A, Ounpraseuth S, Okun MS, et al. Micrographia and related deficits in Parkinson’s disease: a cross-sectional study. BMJ Open 2012; 2 (3): e000628