Historically, the terms young-onset and early-onset Parkinson’s disease have been used for research of Parkinson’s disease that presents before the typical age.1 The International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson’s Disease have recommended that the term ‘early-onset Parkinson’s disease’ be used, and that it refers to people with Parkinson’s disease symptom onset from 21 to under 50 years of age.1
References:
1.Mehanna R, Smilowska K, Fleisher J, et al.; International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson’s Disease. Age cutoff for early-onset Parkinson’s disease: recommendations from the International Parkinson and Movement Disorder Society Task Force on Early Onset Parkinson’s Disease. Mov Disord Clin Pract 2022; 9 (7): 869–878.
2.Schrag A, Schott JM. Epidemiological, clinical, and genetic characteristics of early-onset parkinsonism. Lancet Neurol 2006; 5 (4): 355–363.
3.Lunati A, Lesage S, Brice A. The genetic landscape of Parkinson’s disease. Rev Neurol (Paris) 2018; 174 (9): 628–643.
4.Riboldi GM, Frattini E, Monfrini E, et al. A practical approach to early-onset Parkinsonism. J Parkinsons Dis 2022; 12 (1): 1–26.
5.Lim SY, Tan AH, Ahmad-Annuar A, et al. Uncovering the genetic basis of Parkinson’s disease globally: from discoveries to the clinic. Lancet Neurol 2024: S1474–4422 (24) 00378-8.
