Dyskinesia and motor fluctuations

Whilst the above image shows a typical pattern of levodopa-related motor fluctuations and dyskinesias, adjunctive treatments can prolong ON time, reduce OFF time, and ameliorate dyskinesias.^1,3

References:
1. Stacy M. Medical treatment of Parkinson disease. Neurol Clin 2009; 27 (3): 605–631.

2. Chapuis S, Ouchchane L, Metz O, et al. Impact of the motor complications of Parkinson’s disease on the quality of life. Mov Disord 2005; 20 (2): 224–230.

3. Connolly BS, Lang AE. Pharmacological treatment of Parkinson disease: a review. JAMA 2014; 311 (16): 1670–1683.