The first step is to rule out pseudo non-response

The Section For Evidence-Based Medicine in Psychiatry & Psychotherapy website provides useful tools for determining appropriate antipsychotics doses.

Dose calculator websites:

• The Section For Evidence-Based Medicine in Psychiatry & Psychotherapy, https://ebmpp.org/helpful-tools/³
• Illuminatum, https://illuminatum.com/⁴

References:

1. Leucht S, Siafis S, McGrath JJ, et al. Schizophrenia. Nat Rev Dis Primers 2025; 11(Suppl 1):7.

2. McAdam MK, Baldessarini RJ, Murphy AL, et al. Second International Consensus Study of Antipsychotic Dosing (ICSAD-2). J Psychopharmacol 2023; 37: 982–991.

3. EBMpp. Helpful tools. 2026. https://ebmpp.org/helpful-tools/. Accessed June 12, 2026.

4. Illuminattum. Schizophrenia. 2025. Available at: https://illuminatum.com/. Accessed May 28, 2026.