Slide DecksSchizophrenia – Treatment PrinciplesThe debate around relapses and supersensitivity psychosis being ‘toxic’ for the brain (II) The debate around relapses and supersensitivity psychosis being ‘toxic’ for the brain (II) Schizophrenia south References: 1. Takeuchi H, Siu C, Remington G, et al. Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia. Neuropsychopharmacology 2018; 44: 1036–1042. 2. Silvestri S, Seeman MV, Negrete JC, et al. Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study. Psychopharmacology (Berl) 2000; 152: 174–180. 3. Ginovart N, Wilson AA, Hussey D, et al. D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats. Neuropsychopharmacology 2009; 34: 662–671. file_download Download slide in HQ Published 04.08.2026 Permissions For usage star_border Save share Share