file_download Download slide

Index for
slide deck

Title

SleepAndScz - slide 1
Prediction: There is a mechanistic relationship between mental health and sleep ​
file_download Download slide
SleepAndScz - slide 2
How bad is sleep and circadian rhythm disruption in schizoprenia?
These results are from the study by Foster and colleagues in which the sleep-wake activity and circadian rhythms of 20 patients with schizophrenia and 21 healthy controls were compared over a period of six weeks. This image is the sleep…
file_download Download slide
SleepAndScz - slide 3
How bad is sleep and circadian rhythm disruption in schizoprenia?
References
Wulff K., et al. Br J Psychiatry 2012; 200(4):308-16
file_download Download slide
SleepAndScz - slide 4
How bad is sleep and circadian rhythm disruption in schizoprenia?
Exposure to ambient light was significantly less in patients with schizophrenia than in healthy controls. This may have impaired setting of the internal clock and the circadian melatonin rhythm.
References
Wulff K., et al. Br J Psychiatry 2012; 200(4):308-16
file_download Download slide
SleepAndScz - slide 5
How bad is sleep and circadian rhythm disruption in schizoprenia?
This slide shows a comparison of the electroencephalogram (EEG) patterns of an unemployed control subject (top panel) and a patient with schizophrenia (lower panel). It shows fragmentation of sleep stages in the patient. There is less REM sleep and less…
file_download Download slide
SleepAndScz - slide 6
How bad is sleep and circadian rhythm disruption in schizoprenia?
file_download Download slide
SleepAndScz - slide 7
Prediction: There is a mechanistic relationship between mental health and sleep ​
References

Wulff K., et al. Nat Rev Neurosci 2010; 11(8):589-99

file_download Download slide
SleepAndScz - slide 8
Prediction: There is a mechanistic relationship between mental health and sleep ​
file_download Download slide
SleepAndScz - slide 9
Prediction: There is a mechanistic relationship between mental health and sleep ​
Sleep is associated with many important and restorative processes. These include consolidation of memory, information processing, tissue repair and rebuilding of metabolic pathways, and clearance of toxins, including beta-amyloid. Sleep draws upon all of the neurotransmitters of the brain and…
file_download Download slide
SleepAndScz - slide 10
Prediction: There is a mechanistic relationship between mental health and sleep ​
file_download Download slide
SleepAndScz - slide 11
Treating sleep and circadian rhythm disruption in patients with persecutory delusions​
References
Myers E, et al. J Behav Ther Exp Psychiatry. 2011;42(3):330-336.
file_download Download slide
SleepAndScz - slide 12
Partial consolidation of sleep and circadian rhythm disruption using CBT reduces symptoms in schizophrenia​

Sleep may represent a new therapeutic target, both in the prevention of mental illness and its treatment. There is evidence from a pilot study that cognitive behaviour therapy for insomnia can improve the condition of schizophrenic patients with persistent persecutory…

file_download Download slide
SleepAndScz - slide 13
Prediction: There is a mechanistic relationship between mental health and sleep ​
24h rhythms have their origins within the brain. If we look at the base of the brain – where the optic nerves fuse and enter the brain. The small region above this site – deep within the brain – contains…
file_download Download slide