Inflammation and Brain Disorders: A series of Articles

Neuroinflammation, either directly occurring in the brain from microglial activation or indirectly from peripherally generated immune modulators, is becoming apparent as a component of a number of brain disorders, including Alzheimer’s disease, depression, bipolar disorder and schizophrenia.

description Article Dandelion in the wind
A Perspective on Inflammation in Alzheimer’s Disease

In familial disease associated with PSEN-1 mutations, symptomatic carriers show progressive loss of cortical thickness in areas involved in Alzheimer’s Disease (AD). In contrast, in asymptomatic carriers increased thickness suggests that inflammatory processes or reactive neuronal hypertrophy may be involved in the preclinical phase. Further evidence of a non-linear trajectory in neuroanatomical changes comes from studies relating cortical thickness to beta-amyloid levels in CSF. The context for such studies is growing interest in diagnosing early stages of AD through biomarkers rather than clinical signs and symptoms.

29.07.2019 Alzheimer’s Disease
description Article Inflammation, Accelerated Aging and Structural Brain Changes in Schizophrenia
Inflammation, Accelerated Aging and Structural Brain Changes in Schizophrenia

This article addresses the blood-borne factors related to inflammation and aging, heterogeneity within schizophrenia and the hypothesis that people with schizophrenia experience pathological aging

12.08.2019 Schizophrenia
description Article Man in front of window
Inflammation in Mood Disorders: A New Day or a False Dawn?

This article investigates Major Depressive Disorder (MDD) and the relationship between inflammatory markers and treatment response and resistance.

26.08.2019 Depression

Currated collections

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Non-motor Symptoms in Parkinson’s Disease

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Mental Health

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Inflammation and Brain Disorders: A series of Articles

Neuroinflammation, either directly occurring in the brain from microglial activation or indirectly from peripherally generated immune modulators, is becoming apparent as a component of a number of brain disorders, including Alzheimer's disease, depression, bipolar disorder and schizophrenia.
play_circle 4 videos
video

Applied Biostatistics

In this video series, Professor Christoph Correll presents "Applied biostatistics". Professor Christoph Correll explains the basics of biostatistics, the different designs and hypothesis testing, how power, effect size and sample size are calculated and how to analyze the data.
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Microbiome and Parkinson's disease

The explosion of knowledge of the gut microbiome, occasioned by the developing high throughput measurement of the genetic signatures of the myriad of different gut bacteria, may be the most significant advance in human biology since the cracking of the genetic code. As well as offering remarkable new treatments for…
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When “Patients” are not “Patients” (Yet)

In this four-part series, we explore how earlier detection of brain disorders could improve patient care. Part 1 in this series introduces the concept of prodromal and preclinical disease—a state in which patients have markers of a disease but few or no symptoms. Part 2 focuses on efforts to identify…
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Brain imaging for psychiatrists: A series of articles

Brain imaging has advanced massively in the past two decades. Modern tools such as positron emission tomography (PET), magnetic resonance imaging (MRI) and Magnetoencephalography (MEG) allow us a much clearer view of how the brain works: we can almost literally “look inside the skull”. This series of articles introduces the…
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