When a nerve impulse arrives at a 5-HT or noradrenaline nerve terminal the neurotransmitter is released from the synaptic vesicle into the synaptic cleft. Neurotransmitter molecules bind to their specific receptors on the post-synaptic membrane and the nerve impulse is propagated or inhibited, depending on the receptor type. 5-HT and noradrenaline molecules are then released from their receptors and taken back into the nerve terminal via either the 5-HT or noradrenaline re-uptake transporters. 5-HT and noradrenaline are degraded by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), these enzymes are found in the nerve terminal.1,2

Click here: Learn about the normal processes of serotonin and noradrenaline synaptic activity

file_download Download in HQ

Related content

image Image
Non-motor symptoms common in Parkinson’s disease

A table that provides you an overview on non-motor symptoms common in Parkinson’s disease

02.04.2025 Parkinson’s Disease
The Heterogeneity of Depression and Immunometabolic Depression play_circle Video play_circle
The Heterogeneity of Depression and Immunometabolic Depression

Professor Dr. Brenda Penninx discusses the heterogeneity of major depressive disorder, with specific reference to immunometabolic depression

31.03.2025 Depression
grid_view Slide Deck
Parkinson’s Disease – Non-motor Symptom Complex and Comorbidities

In this slide deck, cognitive disorders, mood disorders, quality of life and the comorbidities of PD are discussed

16.03.2025 Parkinson’s Disease