Abnormalities in blood flow to the brain, as well as CVD cause dementia.1 It has been well established that dementia symptoms represent neuronal loss resulting from the progressive accumulation of dysfunctional brain proteins – a process called proteinopathy. 1 Particularly characteristic of AD is the accumulation of Aβ and phosphorylated tau.1 Distinct proteinopathies may cause similar symptoms if they impact similar brain circuits.1 Additionally, as the accumulation of the dysfunctional proteins may begin several years before the onset of symptoms, dementia represents an advanced stage of various brain proteinopathies.1
References:
1.Gauthier S, Rosa-Neto P, Morais JA, Webster C. World Alzheimer Report 2021: Journey through the diagnosis of dementia. Available at: https://www.alzint.org/u/World-Alzheimer-Report-2021.pdf. Accessed 15 November 2023.