CBT and imipramine in panic disorder

The combination of CBT and imipramine was compared with either treatment alone in 312 patients with panic disorder in a randomized, placebo-controlled trial.¹ Response was defined as much improved or better in Clinical Global Impression – Improvement score while being rated as mild or less in Clinical Global Impression – Severity score.¹ Response rates were not significantly different between treatment groups (by pairwise comparisons) after the 3-month acute treatment phase or at the end of the 6-month follow-up phase.¹

Reference:
1. Barlow DH, Gorman JM, Shear MK, Woods SW. Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. JAMA 2000; 283 (19): 2529–2536.