Many different approaches to treatment are being investigated for use in bipolar disorder.
References:
1. ClinicalTrials.gov website. Available at: www.clinicaltrials.gov. Accessed February 2024.
2. Husain MI, Chaudhry IB, Khoso AB, et al. Minocycline and celecoxib as adjunctive treatments for bipolar depression: a multicentre, factorial design randomised controlled trial. Lancet Psychiatry 2020; 7 (6): 515–527.
3. Rodolico A, Cutrufelli P, Di Francesco A, et al. Efficacy and safety of ketamine and esketamine for unipolar and bipolar depression: an overview of systematic reviews with meta-analysis. Front Psychiatry 2024; 15: 1325399.
4. Preskorn SH, Zeller S, Citrome L, et al. Effect of sublingual dexmedetomidine vs placebo on acute agitation associated with bipolar disorder: a randomized clinical trial. JAMA 2022; 327 (8): 727–736.
5. IgalmiTM (dexmedetomidine) sublingual film. Prescribing information, July 2022.