Given the significant impact of psychiatric comorbidities on patients’ overall morbidity burden and their general quality of life, appropriate identification and treatment of any psychiatric comorbidities in people with epilepsy is crucial for effective treatment.2 Moreover, in the meta-analysis by Kwon et al. summarized on the slide, the authors were careful to emphasize that many patients with epilepsy will have multiple comorbid psychiatric disorders, potentially putting them at risk for additional, more severe psychiatric complications, or other adverse outcomes (e.g., cognitive problems, suicidality).2,3 As such, routine screening for psychiatric comorbidities with reliable and validated tools is recommended by multiple epilepsy treatment guidelines,2 and people with epilepsy and any psychiatric comorbidity should receive a comprehensive individualized treatment plan, developed in cooperation with a multidisciplinary team of neurologists, psychiatrists, clinical psychologists and social workers to ensure the best treatment outcomes.3

References:

1.Gaitatzis A, Trimble MR, Sander JW. The psychiatric comorbidity of epilepsy. Acta Neurol Scand 2004; 110 (4): 207–220.

2.Kwon C, Rafati A, Ottman R, et al. Psychiatric comorbidities in persons with epilepsy compared with persons without epilepsy: a systematic review and meta-analysis. JAMA Neurol 2025; 82 (1): 72–84.

3.Mula M, Kanner AM, Jetté N, Sander JW. Psychiatric comorbidities in people with epilepsy. Neurol Clin Pract 2021; 11 (2): e112–e120.

4.Berg AT, Caplan R, Hesdorffer DC. Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy. Epilepsy Behav 2011; 20 (3): 550–555.