Synchronization in epilepsy and seizures may increase or decrease, i.e., desynchronization.2 Synchronization is determined according to how it changes over time – an increasing trend in coupling between microdomains indicates synchronization, whereas a decrease in coupling indicates desynchronization.2 Desynchronization may be deemed to be present if the trend falls below a certain threshold.2
References:
1. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017; 58 (4): 522‒530.
2. Jiruska P, de Curtis M, Jefferys JGR, et al. Synchronization and desynchronization in epilepsy: controversies and hypotheses. J Physiol 2013; 591 (4): 787‒797.