Various known structural changes in the brain are thought to underly some cases of epilepsy, changing the susceptibility to seizures.1-3
References:
1.Leventer RJ, Guerrini R, Dobyns WB. Malformations of cortical development and epilepsy. Dialogues Clin Neurosci 2008; 10 (1): 47–62.
2.Oegema R, Barakat TS, Wilke M, et al. International consensus recommendations on the diagnostic work-up for malformations of cortical development. Nat Rev Neurol 2020; 16 (11): 618–635.
3.Whelan CD, Altmann A, Botía JA, et al. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study. Brain 2018; 141 (2): 391–408.
4.Pease M, Gonzalez-Martinez J, Puccio A, et al. Risk factors and incidence of epilepsy after severe traumatic brain injury. Ann Neurol 2022; 92 (4): 663–669.
5.Fordington S, Manford M. A review of seizures and epilepsy following traumatic brain injury. J Neurol 2020; 267 (10): 3105–3111.
