The blood–brain barrier

The blood–brain barrier is the complex, highly-selective barrier controlling what macro-molecules and immune cells may enter the brain.¹ However, as summarised on the slide, after epileptogenic brain insults this barrier can become dysfunctional.¹ More research is needed to better understand the functioning of the blood–brain barrier in epilepsy, and help patients by developing novel therapeutic interventions.¹

Reference:

1.Löscher W, Friedman A. Structural, molecular, and functional alterations of the blood–brain barrier during epileptogenesis and epilepsy: a cause, consequence, or both? Int J Mol Sci 2020; 21 (2): 591.