Small animal models versus large-animal models

There are benefits and disbenefits to using small-animal and large-animal models – as outlined on the slide – that must be balanced against each other.^1-3

References:

1.Grone BP, Baraban SC. Animal models in epilepsy research: legacies and new directions. Nat Neurosci 2015; 18 (3): 339–343.

2.Baraban SC. A zebrafish-centric approach to antiepileptic drug development. Dis Model Mech 2021; 14 (7): dmm049080.

3.Davis KA, Sturges BK, Vite CH, et al. A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG. Epilepsy Res 2011; 96 (1–2): 116–122.