This slide summarises the increased risk that the presence of depressive symptoms confers on an individual for developing a variety of comorbid conditions. Many of these relationships are thought to be bidirectional – i.e., one increases the chances of the other and vice versa – and this complexity reinforces the need for integrated models of care that take into account the patient as a whole.
References:
1.Rickelt J, Viechtbauer W, Lieverse R, et al. The relation between depressive and obsessive–compulsive symptoms in obsessive–compulsive disorder: results from a large, naturalistic follow-up study. J Affect Disord 2016; 203: 241–247.
2.Dold M, Bartova L, Souery D, et al. Low comorbid obsessive-compulsive disorder in patients with major depressive disorder – findings from a European multicenter study. J Affect Disord 2018; 227: 254–259.
3.Thaipisuttikul P, Ittasakul P, Waleeprakhon P, et al. Psychiatric comorbidities in patients with major depressive disorder. Neuropsychiatr Dis Treat 2014; 10: 2097–2103.
4.Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62 (6): 593–602.
5.Kessler RC. The prevalence of psychiatric comorbidity. In: Wetzler S, Sanderson WC (eds). An Einstein Psychiatry Publication, No. 14. Treatment Strategies for Patients with Psychiatric Comorbidity. John Wiley & Sons Inc. 1997.
6.Bron TI, Bijlenga D, Verduijn J, et al. Prevalence of ADHD symptoms across clinical stages of major depressive disorder. J Affect Disord 2016; 197: 29–35.
7.Cha DS, Carvalho AF, Rosenblat JD, et al. Major depressive disorder and type II diabetes mellitus: mechanisms underlying risk for Alzheimer’s disease. CNS Neurol Disord Drug Targets 2014; 13 (10): 1740–1749.
8.Chen R, Hu Z, Wei L, et al. Severity of depression and risk for subsequent dementia: cohort studies in China and the UK. Br J Psychiatry 2008; 193 (5): 373–377.
9.Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 2008; 31 (12): 2383–2390.
10.Gan Y, Gong Y, Tong Y, et al. Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies. BMC Psychiatry 2014; 14: 371.
11.Wu EL, Chien IC, Lin CH, et al. Increased risk of hypertension in patients with major depressive disorder: a population-based study. J Psychosom Res 2012; 73 (3): 169–174.
12.Jia Y, Li F, Liu YF, et al. Depression and cancer risk: a systematic review and meta-analysis. Public Health 2017; 149: 138–148.
