Chronic pain

Migraine is often comorbid with chronic pain.^{[Hagen et al., 2002; Peterlin et al., 2010; Woldeamanuel et al., 2017]} Indeed, migraine and complex regional pain syndrome (CRPS) are thought to share some pathology and clinical characteristics.^{[Woldeamanuel et al., 2017]} In one study, the coexistence of migraine and CRPS was associated with poorer clinical outcomes, and greater psychiatric comorbidity, than migraine alone.^{[Woldeamanuel et al., 2017]}

References:
Hagen K, Einarsen C, Zwart JA, et al. The co-occurrence of headache and musculoskeletal symptoms amongst 51,050 adults in Norway. Eur J Neurol 2002; 9 (5): 527–533.

Peterlin BL, Rosso AL, Nair S, et al. Migraine may be a risk factor for the development of complex regional pain syndrome. Cephalalgia 2010; 30 (2): 214–223.

Woldeamanuel YW, Cooley C, Foley-Saldena K, Cowan RP. Migraine and complex regional pain syndrome: a case-referent clinical study. Biomed Res Int 2017; 2017: 5714673.

Other reference used on slide:
Wang SJ, Chen PK, Fuh JL. Comorbidities of migraine. Front Neurol 2010; 1: 16.