A variety of gastrointestinal (GI) disorders have been investigated in people with migraine, and in some cases people with migraine are at a higher risk of GI conditions than the general population.[Cámara-Lemarroy et al., 2016; van Hemert et al., 2014] The possible involvement of the gut–brain axis in the pathology of migraine has led some to explore the possibility of probiotic treatments for migraine symptoms.[van Hemert et al., 2014] In a variety of studies, probiotics have been shown to improve the functioning of the gut.[van Hemert et al., 2014] An exploratory, uncontrolled study in 40 people with migraine found that a combination of probiotics and nutritional supplements, taken over a period of three months, appeared to increase quality of life scores, and migraine remitted in 60% of participants.[Sensenig et al., 2001]

References:
Cámara-Lemarroy CR, Rodriguez-Gutierrez R, Monreal-Robles R, Marfil-Rivera A. Gastrointestinal disorders associated with migraine: a comprehensive review. World J Gastroenterol 2016; 22 (36): 8149–8160.

Sensenig J, Marrongelle J, Johnson M, Staverosky T. Treatment of migraine with targeted nutrition focused on improved assimilation and elimination. Altern Med Rev 2001; 6 (5): 488–494.

van Hemert S, Breedveld AC, Rovers JMP, et al. Migraine associated with gastrointestinal disorders: review of the literature and clinical implications. Front Neurol 2014; 5: 241.

Other references used on slide:
Aurora SK, Shrewsbury SB, Ray S, et al. A link between gastrointestinal disorders and migraine: insights into the gut-brain connection. Headache 2021; 61 (4): 576–589.

Gonzalez A, Hyde E, Sangwan N, et al. Migraines are correlated with higher levels of nitrate-, nitrite-, and nitric oxide-reducing oral microbes in the American Gut Project Cohort. mSystems 2016; 1 (5): e00105–16.