Various approaches have been taken to unravel the complex genetics of headache and migraine disorders.[Sutherland et al., 2019] Linkage mapping analysis can trace genetic markers and candidate genes in family pedigrees of monogenic headache disorders.[Sutherland et al., 2019] For polygenic causes of headache disorders, the more powerful sequencing techniques that have become available since the turn of the century allow genome-wide association studies (GWAS), which have greatly expanded the understanding of the many genetic components and common pathways of headache and migraine disorders.[Sutherland et al., 2019]
Other reference used on slide:
van den Maagdenberg AMJM, Nyholt DR, Anttila V. Novel hypotheses emerging from GWAS in migraine? J Headache Pain 2019; 20 (1): 5.