Various different migraine triggers have been identified, including emotional, physical, dietary, and environmental factors.[Migraine Trust; Pavlovic et al., 2014; Park et al., 2016; Sarchielli, 2006; Turner et al., 2019; Wöber et al., 2006] Migraine triggers are a complex set of seemingly conflicting factors, e.g., both lack of sleep, and too much sleep, are linked to triggering migraine.[Migraine Trust] Some have suggested that the amount of change in the exposure to a trigger is crucial for its effect. [Turner et al., 2019] Designing studies to investigate migraine triggers is methodologically challenging; a putative migraine trigger may only act as a trigger in concert with some other factor, (e.g., alcohol might act as a trigger only when the individual is tired), and determining the dosing of the trigger is difficult – how much is a ‘normal’ dose of chocolate?[Pavlovic et al., 2014] However, if a person identifies factors that they believe triggers their migraine attacks, this opens up the possibility of pre-emptive therapy.[Pavlovic et al., 2014] Pre-emptive therapy is a strategy that borrows from acute and preventive treatment, in which patients take medication in advance of an anticipated headache attack in order to prevent its onset.[Pavlovic et al., 2014]

References:
Migraine Trust website. https://www.migrainetrust.org/about-migraine/trigger-factors/common-triggers/. Accessed May 2020.

Pavlovic JM, Buse DC, Sollars CM, et al. Trigger factors and premonitory features of migraine attacks: summary of studies. Headache 2014; 54 (10): 1670–1679.

Park JW, Chu MK, Kim JM, et al. Analysis of trigger factors in episodic migraineurs using a smartphone headache diary applications. PLoS One 2016; 11 (2): e014957.

Sarchielli P. Trigger factors of migraine and tension-type headache. J Headache Pain 2006; 7: 172–173.

Turner DP, Lebowitz AD, Chtay I, Houle TT. Headache triggers as surprise. Headache 2019; 59 (4): 495–508.

Wöber C, Holzhammer J, Zeitlhofer J, et al. Trigger factors of migraine and tension-type headache: experience and knowledge of the patients. J Headache Pain 2006; 7 (4): 188–195.

Other references used on slide:
Hagen K, Åsberg AN, Stovner L, et al. Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995–1997 and 2006–2008. Cephalalgia 2018; 38 (13): 1919–1926.

Hoffmann J, Recober A. Migraine and triggers: post hoc ergo propter hoc? Curr Pain Headache Rep 2013; 17 (10): 370.

Lipton RB, Pavlovic JM, Haut SR, et al. Methodological issues in studying trigger factors and premonitory features of migraine. Headache 2014; 54 (10): 1661–1669. Onderwater GLJ, van Oosterhout WPJ, Schoonman GG, et al. Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine. Eur J Neurol 2019; 26 (4): 588–595.