In addition to the factors outlined on the slide, research also highlights the role of epigenetic mechanisms, which may mediate the interplay between genetic predisposition and environmental influences.4 These mechanisms include processes such as DNA methylation, histone modification, and regulation by non‑coding RNAs.4
Abbreviations: DNA=deoxyribonucleic acid; RNA=ribonucleic acid
References:
1. McCutcheon RA, Reis Marques T, Howes, OD. Schizophrenia-an overview. JAMA Psychiatry 2020; 77: 201–210.
2. Jauhar S, Johnstone M, McKenna PJ. Schizophrenia. Lancet 2022; 399: 473–486.
3. Leucht S, Siafis S, McGrath JJ, et al. Schizophrenia. Nat Rev Dis Primers 2025; 11: 83.
4. Thorat N, Kulkarni S. Epigenomics and schizophrenia: a literature review. BJPsych Open 2025; 11: S52–S53.