The figure summarizes how common‑variant genetic risk is shared across 8 psychiatric disorders, using genome-wide genetic correlations calculated with LD score regression.2 Within this structured pattern of shared genetic risk, schizophrenia and bipolar disorder show strong overlap.2,3
Abbreviations: FDR=false discovery rate; LD=linkage disequilibrium
References:
1. Trubetskoy V, Pardiñas AF, Qi T, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022; 604: 502–508.
2. Wingo TS, Liu Y, Gerasimov ES, et al. Shared mechanisms across the major psychiatric and neurodegenerative diseases. Nat Commun 2022; 13: 4314.
3. Grotzinger AD, Werme J, Peyrot WJ, et al. Mapping the genetic landscape across 14 psychiatric disorders. Nature 2026; 649: 406–415.