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  • Schizophrenia – Aetiology and neurobiology
  • Genetic risk for schizophrenia converges on specific biological pathways

Genetic risk for schizophrenia converges on specific biological pathways

Schizophrenia
Slide showing convergence of schizophrenia risk variants on shared biological pathways.

References:
1. Rosato M, Stringer S, Gebuis T, et al. Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes. Mol Psychiatry 2021; 26: 784‒799.
2. Sullivan PF, Yao S, Hjerling-Leffler J. Schizophrenia genomics: genetic complexity and functional insights. Nat Rev Neurosci 2024; 25: 611‒624.
3. Sekar A, Bialas AR, de Rivera H, et al. Schizophrenia risk from complex variation of complement component 4. Nature 2016; 530: 177‒183.
4. Trubetskoy V, Pardiñas AF, Qi T, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022; 604: 502–508.
5. Benjamin KJM, Chen Q, Jaffe AE, et al. Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes. Nat Neurosci 2022; 27: 1559‒1568.

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Published 23.06.2026
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