A Danish study of over 6.9 million residents aimed to calculate YLD for 18 mental and substance use disorders.2 Schizophrenia was associated with 225.0 (95% CI: 190.0, 258.0) YLD per 100,000 person-years in females and 322.6 (274.1, 370.7) YLD per 100,000 person-years in males.2 When analyzed by subgroup (i.e., individuals with a specific mental or substance use disorder), schizophrenia was associated with the highest estimated YLD, at 65,872 (55,791–75,533) per 100,000 person-years across both sexes.2
Abbreviations: CI=confidence interval; YLD=years lived with disability
References:
1.GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry 2022; 9: 137–150.
2.Weye N, Santomauro DF, Agerbo E, et al. Register-based metrics of years lived with disability associated with mental and substance use disorders: a register-based cohort study in Denmark. Lancet Psychiatry 2021; 8: 310–319.
3.Institute for Health Metrics and Evaluation (IHME). GBD Compare Data Visualization. Seattle, WA: IHME, University of Washington, 2025. Available from https://vizhub.healthdata.org/gbd-compare.
