As shown on the slide, using data from the 2019 GBD, substance use and addiction contribute to the global burden of disease.[1] Interesting changes to the contribution of risk factor-attributable burden have occurred over the last few decades.[1] However, one risk factor remained unchanged; among people aged 25–49 years, alcohol use was the leading risk factor, contributing to 6.79% of disability-adjusted life year (DALYs) burden in 1990, and 6.3% of DALYs in 2019.[1]

Reference:
[1] GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 2020; 396 (10258): 1223–1249.