Dementia care is facing immense challenges worldwide, with the growing number of diagnoses and lack of effective therapies. In this video, Professor Matthew Kiernan discusses the complexities of dementia research, including recent insights into neurobiological aetiologies, and promising developments for therapeutics. From targeted monoclonal antibody treatments for specific proteins linked to various forms of dementia, to the critical role of lifestyle and preventative care, Professor Kiernan outlines a multifaceted approach to tackling this global issue.
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Social and physical exposome factors—like poverty, pollution, and inequality—accumulate over time, shaping biological aging and cognitive decline. Through inflammation and cellular stress, these exposures drive neurodegeneration, highlighting the need for longitudinal, integrative research.
The exposome reframes dementia as the product of cumulative physical and social exposures-like pollution, nutrition, and inequality-across life. These factors shape brain aging through inflammation and epigenetic change. Lifespan, global studies are key to equitable dementia prevention.
