Insulin receptors are widely expressed throughout the brain, with high concentrations in regions such as the prefrontal cortex, striatum, hippocampus, hypothalamus and amygdala. Insulin acting within these brain regions exerts several downstream central and peripheral actions.
Related content
Physical Health in Mental Disorders: Burden and Solutions
Physical health and mental disorders are closely linked, with mental–physical comorbidity posing a major global public health and equity challenge.
12.03.2026
Schizophrenia
Main organ systems affected by physical comorbidities in people with mental disorders
Across mental disorders, physical comorbidities commonly affect multiple organ systems, most notably cardiometabolic and respiratory systems.
12.03.2026
Schizophrenia
Key actions for clinicians to address physical–mental comorbidity
Actions to address physical–mental comorbidity.
12.03.2026
Schizophrenia