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image Image Infographic showing central and peripheral biological systems contributing to depression, including neurotransmitters, brain structure, immune response, and gut-brain axis.
Biological factors driving depression

This diagram outlines how neurotransmitters, brain function, immune signaling, and microbiota interact to drive depressive symptoms.

29.07.2025 Depression
image Image Diagram illustrating how genome, epigenome, and environmental factors interact through molecular pathways to influence synaptic function and behavior in depression.
The molecular basis of depression

This image visualizes the molecular cascade—from genome to synaptic structure—showing how depression develops through genetic, chemical, and environmental interactions.

29.07.2025 Depression
image Image Chart showing levels of depression severity including sub-threshold symptoms, mild, moderate, and severe depression, with corresponding MADRS scores.
Levels of depression severity

Understand the different levels of depression severity and how they are classified using the MADRS scale — from mild to severe forms.

28.07.2025 Depression
image Image Table comparing DSM-5-TR and ICD-11 depression diagnostic criteria with symptoms such as depressed mood, anhedonia, fatigue, and suicidal thoughts.
Signs and symptoms of depression – diagnostic criteria

A side-by-side comparison of DSM-5-TR and ICD-11 criteria for diagnosing depression, including common symptoms like sleep problems and cognitive issues.

28.07.2025 Depression
image Image Mechanism-based subtyping to inform targeted therapies
Mechanism-based subtyping to inform targeted therapies

Precision psychiatry aims to move beyond traditional symptom-based diagnostic frameworks which group biologically heterogeneous patients under the same diagnosis.

28.07.2025 Depression
image Image The immunopsychiatry continuum
The immunopsychiatry continuum

On the continuum of immune-mediated mechanisms contributing to psychiatric symptoms, the relative contribution of immune activation differs across patient groups.

28.07.2025 Depression

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