Migraine affects an estimated 1.1 billion people worldwide and ranks as the 2nd leading cause of disability, while being the leading among young adults.1,2,3 There is a female predominance of approximately 2:1, and the prevalence surges throughout puberty, peaks around age forty, and finally declines in the elderly. Migraine without aura is the most common form, whereas a third experience attacks of migraine with aura either exclusively or in addition to attacks without aura.
Related content
Migraine is a prevalent neurological disorder characterized by recurrent and disabling attacks of moderate to severe headache
In human models of migraine, a suspected pharmacological migraine trigger is administered either orally or via infusion to a participant with migraine or a healthy volunteer, typically within a double-blinded, randomized, placebo-controlled design
The trigeminovascular system is recognized as the anatomical and physiological substrate of migraine