A person’s environment may interact with the genetics of MDD, causing epigenetic changes that may drive brain changes in people with depression.1,2
Environmental factors may significantly impact gene expression in people with MDD through epigenetic mechanisms.1 For example, child abuse is associated with epigenetic reprogramming of oligodendrocytes, with possible lasting adverse effects on cortical myelination in people with MDD who experienced childhood abuse compared with people with MDD who did not.1
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