A search of the published literature up to December 2021 found reports of 881 genes implicated in epilepsy.6 The average number of Tier 1 (epilepsy) genes identified per year between 1992 and 2021 was 4.8, with the highest Tier 2 (epilepsy candidate) gene average over a decade reported between 2010 and 2019 (7.1).6
References:
1. Berkovic SF, McIntosh A, Howell RA, et al. Familial temporal lobe epilepsy: A common disorder identified in twins. Ann Neurol 1996; 40 (2): 227‒235.
2. Grinton BE, Heron SE, Pelekanos JT, et al. Familial neonatal seizures in 36 families: Clinical and genetic features correlate with outcome. Epilepsia 2015; 56 (7): 1071‒1080.
3. Krey I, Platzer K, Esterhuizen A, et al. Current practice in diagnostic genetic testing of the epilepsies. Epileptic Disord 2022; 24 (5): 765‒786.
4. McTague A, Howell KB, Cross JH, et al. The genetic landscape of the epileptic encephalopathies of infancy and childhood. Lancet Neurol 2016; 15 (3): 304‒316.
5. Johannesen KM, Tumer Z, Weckhuysen S, et al. Solving the unsolved genetic epilepsies: Current and future persceptives. Epilepsia 2023; 64 (12): 3143‒3154.
6. Macnee M, Pérez-Palma E, López-Rivera JA, et al. Data-driven historical characterization of epilepsy-associated genes. Eur J Paediatr Neurol 2023; 42: 82‒87.