Narrow- vs broad-spectrum ASMs for newly diagnosed patients

Lamotrigine and oxcarbazepine are known to occasionally aggravate myoclonic seizures and are therefore not recommended.^1,4

References:

1.Löscher W, Klein P. The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond. CNS Drugs 2021; 35 (9): 935‒963.

2.Cheng JY, French JA. Intelligent use of antiepileptic drugs is beneficial to patients. Curr Opin Neurol 2018; 31 (2): 169‒175.

3.Guerrini R, Balestrini S, Wirrell EC, Walker MC. Monogenic epilepsies: Disease mechanisms, clinical phenotypes, and targeted therapies. Neurology 2021; 97 (17): 817‒831.

4.Kanner AM, Bicchi MM. Antiseizure medications for adults with epilepsy: A review. JAMA 2022; 327 (13): 1269–1281.