The exact mechanisms by which the ketogenic diet and Atkins diet work in people with epilepsy are unclear, but it has been suggested that they may have anti-inflammatory and neuromodulatory effects via gene expression, metabolism in the brain, and the gut microbiome.1

References:

1.Friedman D. Surgical treatments, devices, and nonmedical management of epilepsy. Continuum (Minneap Minn) 2025; 31 (1): 165‒186.

2.Chang P, Augustin K, Boddum K, et al. Seizure control by decanoic acid through direct AMPA inhibition. Brain 2016; 139 (2): 431‒443.